Research & Innovation Services

Paul Giacomin

Paul Giacomin

Arnold Mangott

Arnold Mangott

Personal Protective Biosystems - Membranes and commensal helminths (MaCH) (Old ID 26776)
Paul Giacomin
15 Apr 2021 - 14 Apr 2026
The proposed work will design a 2-part protective biosystem capable of dramatically reducing the burden of personal protective equipmetn (PPE). The first component consists of a garmetn system with a dynamic, selectively permeable graphene composite barrier laqyer and integrated self-cleaning functionality provided by metal oranic frameworks. The sedon component (including work to be done at JCU) leverages genetic modification of human helminth parasites (hookworms and/or schistosomes) to provide prophylaxis and neutralisation of various chemical and/or biological agents.
Novel biologics for pediatric inflammatory bowel disease and necrotising enterocolitis, inspired by host-parasite co-evolution. (Old ID 27128)
Paul Giacomin
01 Feb 2021 - 31 Aug 2022
Inflammatory bowel diseases (IBD) pose a major health burden with severe symptoms, and IBD onset in childhood is on the rise. Necrotising enterocolitis (NEC) is another inflammatory bowel condition that affects preterm infants, and in which inflamed parts of the gut die. Current treatment methods are insufficient. Intestinal parasites have developed strategies to modulate our immune responses through secreted proteins. We identified seven helminth-secreted proteins that suppress gut inflammation. We now would like to assess which of our preselected proteins are best in the context of early life IBD and NEC.

Treatment of mice with S4B6 IL‑2 complex prevents lethal toxoplasmosis via IL‑12‑ and IL‑18‑dependent interferon‑gamma production by non‑CD4 immune cells

Helminth coinfection and COVID-19: an alternate hypothesis

Ulva lactuca as a functional ingredient and water bioremediator positively influences the hepatopancreas and water microbiota in the rearing of Litopenaeus vannamei

Gastrointestinal helminth infection improves insulin sensitivity, decreases systemic inflammation, and alters the composition of gut microbiota in distinct mouse models of Type 2 diabetes

Randomized, placebo controlled trial of experimental hookworm infection for improving gluten tolerance in Celiac disease

A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis

  • 2021
  • Elsevier
  • Researchers:Darren PickeringRoland RuscherMatt FieldNorelle DalyPaul GiacominAlex Loukas

Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy

  • 2021
  • MDPI
  • Researchers:Paul GiacominAlex Loukas

Immune system investigation using parasitic helminths

Editorial: Recent advances in the immunology of helminth infection – protection, pathogenesis and panaceas

Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial

Title: Advance QLD Mid-Career Fellow, James Cook Univers
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2016
End Date: 01 Jan 2019
Title: NHMRC CJ Martin Research Fellow, James Cook University, Cairns
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2012
End Date: 01 Jan 2015
Title: NHMRC CJ Martin Research Fellow, University of Pennsylvania
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2010
End Date: 01 Jan 2012
Title: Research Fellow, University of Pennsylvania
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2009
End Date: 01 Jan 2009
Title: Sir Keith Murdoch Fellow, University of Pennsylvania
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2008
End Date: 01 Jan 2009
Title: PhD candidate, University of Adelaide
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2003
End Date: 01 Jan 2008
Title: BSc (Hons), University of Adelaide
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2002
End Date: 01 Jan 2002
Title: BSc (Biomedical Science), University of Adelaide
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 1999
End Date: 01 Jan 2002