Ketamine-Assisted Psychotherapy Provides Lasting and Effective Results in the Treatment of Depression, Anxiety, and Post-Traumatic Stress Disorder at 3 and 6 Months: Findings from a Large Retrospective Effectiveness Study

Journal Publication ResearchOnline@JCU
Yermus, Ryan;Bottos, John;Bryson, Nathan;De Leo, Joseph A.;Earleywine, Mitch;Hackenburg, Emily;Kennedy, Sidney;Kezemidis, Martha;Kratina, Sarah;McMaster, Robert;Medrano, Ben;Mina, Monica;Morisano, Dominique;Muench, Michael;Pillai, Sabana;Scharlach, Randall;Setlur, Varun;Verbora, Michael;Wolfson, Elizabeth;Zaer, Nabid;Lo, Chris
Chris Lo
Abstract

Importance: Ketamine-assisted psychotherapy (KAP) is an emerging treatment option to alleviate treatment-resistant affective disorders, but its long-term effectiveness remains unclear. Objective: To examine the treatment effects of KAP on anxiety, depression, and post-traumatic stress disorder (PTSD) at 1, 3, and 6 months post-treatment. Design, Setting, and Participants: This retrospective effectiveness study included self-reported outcomes from adults with a history of major depressive disorder, generalized anxiety disorder (GAD), or PTSD who had not responded to prior treatment interventions and received KAP administered across 11 Field Trip Health clinics in North America between March 13, 2020, and June 16, 2022. The evaluable sample sizes were 346 and 94 participants at 3 and 6 months, respectively, representing loss to follow-up rates of 82% and 95%.

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Psychedelic Medicine

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2831-4433

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9

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Mary Ann Liebert

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DOI

10.1089/psymed.2023.0021